Ahmet Alper Ozturk got Bachelor's degree in 2013/June from Anadolu University, Faculty of Pharmacy. He started his PhD programme in 2013/September. Since 2014 he has been working as a Research Assistant at the Department of Pharmaceutical Technology at Anadolu University. He has participated practical studies of ‘Vitamin C loaded liposome formulation and characterization’ by ERASMUS Internship Program at University of Cagliari (Italy) in 2011.
Now a days one of the most important health problem is cancer which is characterized by uncontrolled cellular proliferation. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy; it represent the taxane family of drugs. Paclitaxel's mechanism of action involves its stabilization of cellular microtubules; as a result, it interferes with the normal breakdown of microtubules during cell division. It is effect on the proliferation of tumor cells suppression with by prevent the vascularisation (angiogenesis), cell migration and collagen formation. Therefore, Paclitaxel is used commonly for treatment of lung, ovarian, breast, and head and neck cancers in therapy. Solid lipid nanoparticles (SLNs) were introduced at the beginning of the 1990’s as an alternative to traditional delivery systems such as emulsions, liposomes and polymeric systems. SLNs are nano-sized particles prepared using lipids which are solid at room and body temperatures and which can be stabilized with surfactants. The lipids used are biocompatible compounds with GRAS feature. The objective of this study was to formulate biodegradable and biocompatible cationic lipid delivery systems which is loaded Paclitaxel. After evaluation of the particle size, surface charge and the degree of crystallinity of formulation, cell culture studies were performed for the determination of cytotoxic effects. Colorimetric MTT method was used for the quantitative determination of cell cytotoxicity and MDA and MCF-7 cells were used.
Alain I Mufula is a PhD student at the University of the Witwatersrand, Johannesburg/ South Africa. He is a specialist in synthesis nanocomposite applied in fuel cells.
Fuel cells are of great interest in our society today due to their high efficiency and potential for low emissions. Among all the various kinds of fuel cells, Proton Exchange Membrane Fuel Cell (PEMFC) is believed to be the most promising one for transportation applications because of its fast startup and immediate response to changes in the demand for power and its tolerance to shock and vibration due to plastic materials and immobilized electrolyte. In the energy market, transportation sector is the main oil consumer, for example, in the U.S., transportation consumes about two-thirds of the nation’s oil, and this figure is expected to remain essentially constant through 2020. The research is aimed at production of nanocomposite material based polystyrene-butadiene rubber for better proton conductivity and mechanical properties, in hydrogen fuel cell. The above aim will be achieved through the following objectives: - Optimizing the sulphonation process which is an important process used to render the polymers proton conductive by the using different sulphonating agents such us chlorosulphonic acid , acetic sulphate... etc - Determining the effect of blending using nanomaterials (carbon nanoballs, silica or titania) on the membrane’s properties (proton conductivity, mechanical properties, permeability). - Determining the effect of hydrogenation of the rubber on the membrane properties. Preliminary results revealed that sulphonation process can be optimized by increasing the time of reaction and concentration of sulphonating agents. The blending process has shown improvement in mechanical properties at low feed of nanomaterials. The hydrogenation process had also an effect on the properties of the membrane.